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Heart Protection Study
The ''Heart Protection Study'' was a large randomized controlled trial
run by the Clinical Trial Service Unit, and funded
by the Medical Research Council (MRC) and the British Heart Foundation (BHF) in the United Kingdom. It studied the use of statin (simvastatin 40 mg) medication and vitamin supplementation (vitamin E, vitamin C and beta carotene) in patients who are at risk of cardiovascular disease.
==Results==
An outline of the study protocol was published in 1999.〔''MRC/BHF Heart Protection Study of cholesterol-lowering therapy and of antioxidant vitamin supplementation in a wide range of patients at increased risk of coronary heart disease death: early safety and efficacy experience.'' Eur Heart J 1999;20:725-41. (PDF ). PMID 10329064.〕 Initial results〔Heart Protection Study Collaborative Group. ''MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial.'' Lancet 2002;360:7-22. PMID 12114036.〕 were published in 2002, which indicated that vitamins made little difference in modifying cardiovascular risk, but that simvastatin could significantly reduce the risk of cardiovascular events. Further results, from 2003 and 2004, focused on the role of simvastatin in diabetics〔Collins R, Armitage J, Parish S, Sleigh P, Peto R; Heart Protection Study Collaborative Group. ''MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial.'' Lancet 2003;361:2005-16. PMID 12814710〕 and preventing stroke.〔Collins R, Armitage J, Parish S, Sleight P, Peto R; Heart Protection Study Collaborative Group. ''Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20536 people with cerebrovascular disease or other high-risk conditions.'' Lancet 2004;363:757-67. PMID 15016485.〕 A 2005 paper analyses the cost-effectiveness of a prescribing strategy similar to the one employed in the study.〔Mihaylova B, Briggs A, Armitage J, Parish S, Gray A, Collins R; Heart Protection Study Collaborative Group. ''Cost-effectiveness of simvastatin in people at different levels of vascular disease risk: economic analysis of a randomised trial in 20,536 individuals.'' Lancet 2005;365:1779-85. PMID 15910950.〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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